Journal article
Copy number aberrations in benign serous ovarian tumors: A case for reclassification?
SM Hunter, MS Anglesio, R Sharma, CB Gilks, N Melnyk, YE Chiew, A DeFazio, TA Longacre, DG Huntsman, KL Gorringe, IG Campbell
Clinical Cancer Research | Published : 2011
Abstract
Purpose: Serous ovarian carcinomas are the predominant epithelial ovarian cancer subtype and it has been widely believed that some or all of these may arise from precursors derived from the ovarian surface epithelium or fimbriae, although direct molecular evidence for this is limited. This study aimed to conduct copy number (CN) analysis using a series of benign and borderline serous ovarian tumors to identify underlying genomic changes that may be indicative of early events in tumorigenesis. Experimental Design: High resolution CN analysis was conducted on DNA from the epithelial and fibroblast components of a cohort of benign (N = 39) and borderline (N = 24) serous tumors using the Affymet..
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by U.S. Army Medical Research and Materiel Command
Funding Acknowledgements
This work was supported by a grant (ID 628630) from the National Health and Medical Research Council of Australia (NHMRC). The AOCS was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, The Cancer Council Tasmania, The Cancer Foundation of Western Australia, and the National Health and Medical Research Council of Australia, (NHMRC; IDs 40028 and 400413).